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Desvenlafaxine, as desvenlafaxine succinate, is a novel salt form of the isolated major active metabolite (O-desmethylvenlafaxine) of the SNRI venlafaxine.22Preclinical studies using competitive radioligand binding assays indicate that desvenlafaxine exhibits selective inhibitory activity of neurotransmitter uptake at the human serotonin and … The maximum recommended dose in patients with severe renal impairment (Cl Cr 15 to 29 mL/min, C-G) or end-stage renal disease (ESRD, Cl Cr < 15 mL/min, C-G) is 25 mg every day or 50 mg every other day. Supplemental doses should not be given to patients after dialysis [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. Desvenlafaxine comes in the form of an extended-release tablet you take by mouth. This drug slowly releases into the body over time. 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Adult outpatients with DSM-IV-defined major depressive disorder and a 17-item Hamilton Rating Scale for Depression (HAM-D 17) total score ≥20 were randomly assigned to receive placebo or desvenlafaxine (10 or 50 mg/day) after a 6- to 14-day single-blind placebo lead-in period in an 8-week, phase 3, fixed-dose trial.The primary efficacy measure was change from baseline in the HAM-D. The SNRI desvenlafaxine (administered as desvenlafaxine succinate) is approved by the US Food and Drug Administration for the treatment of adults with MDD. 9 Desvenlafaxine has demonstrated efficacy for treating MDD at the recommended dose of 50 mg/d. 10 In a pooled analysis of 10 desvenlafaxine clinical trials (dose range, 50-400 mg/d), discont... Your Discount Pricing for desvenlafaxine succinate er. 30 50 mg tab er 24h. Edit. PHARMACY. Price with RXgo. Print Your Coupon. You SAVE $323. 97. Estimated Cash Price $343.99. Cost With Our Coupon. $20. 02. USE COUPON.. 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